Drug Information

Drug General Information
Drug ID
D02JIS
Former ID
DNAP001705
Drug Name
Iobenguane I-123
Synonyms
AdreView (TN)
Drug Type
Small molecular drug
Indication Neuroendocrine cancer [ICD10:C7A] Approved [529941]
Company
GE Healthcare
Structure
Download
2D MOL

3D MOL
Formula
C8H10IN3
Canonical SMILES
C1=CC(=CC(=C1)I)CN=C(N)N
InChI
1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,10,11,12)
InChIKey
PDWUPXJEEYOOTR-UHFFFAOYSA-N
CAS Number
CAS 139755-80-9
PubChem Compound ID
60860
PubChem Substance ID
7398973, 11111341, 11111342, 11466518, 11467638, 11486016, 14750688, 24278499, 43118198, 47349354, 47573370, 47646555, 47720604, 48169363, 49698519, 50111105, 56219166, 57314158, 77939172, 85788868, 90341658, 99222771, 103113617, 103113618, 103215608, 104321834, 117356661, 117356662, 124749883, 124880479, 125820672, 127320057, 127320058, 127320059, 127320060, 127320061, 127320062, 127320063, 127320064, 127320065, 127320066, 128901924, 135114605, 137102707, 137138944, 142124139, 162916309, 175427085, 179225831, 179235742
SuperDrug ATC ID
V09IX01
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [543974]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 5299412008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
Ref 543974(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 926).

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