Drug Information

Drug General Information
Drug ID
D09OQV
Former ID
DCL000889
Drug Name
N-0923
Synonyms
Neupro; Rotigotine; Rotigotine CDS; Rotigotine CDS Patch; Rotigotine transdermal patch; N 0437; N 0923; N 0924; SPM 962; N-0437; N-0924; Neupro (TN); Rotigotine [USAN:INN]; SPM-936; SPM-937; SPM-962; Rotigotine (USAN/INN); N 0437, (-)-isomer; (-)-(S)-5,6,7,8-Tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-naphthol; (-)-N-0437; (6S)-6-(Propyl(2-(2-thienyl)ethyl)amino)-5,6,7,8-tetrahydro-1-naphthalenol; (6S)-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol; 2-(N-n-Propyl-N-2-thienylethylamino)-5-hydroxytetralin; 6-(Propyl(2-(2-thienyl)ethyl)amino)-5,6,7,8-tetrahydro-1-naphthalenol; 6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Approved [528061], [529282]
Company
National Cancer Institute (NCI)
Structure
Download
2D MOL

3D MOL
Formula
C19H25NOS
Canonical SMILES
CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O
InChI
1S/C19H25NOS/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21/h3-7,13,16,21H,2,8-12,14H2,1H3/t16-/m0/s1
InChIKey
KFQYTPMOWPVWEJ-INIZCTEOSA-N
CAS Number
CAS 99755-59-6
PubChem Compound ID
59227
PubChem Substance ID
12014593, 14752454, 14752455, 17186146, 43116758, 47207429, 50065448, 50113269, 57313947, 80319505, 92720050, 93308798, 103403788, 104016053, 104317509, 126620376, 126649059, 126652305, 126668282, 128375597, 131331909, 134222775, 134339011, 134339342, 134339911, 134340448, 135016328, 135650929, 137239502, 142666076, 143493345, 144206180, 152240256, 152258902, 160647749, 162011478, 163122815, 170465204, 171578547, 174531819, 175268915, 179151436, 185974303, 187072933, 196106681, 198987592, 204360677, 206711592, 218903400, 223382851
SuperDrug ATC ID
N04BC09
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Agonist [536923]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 528061Rotigotine: a novel dopamine agonist for the transdermal treatment of Parkinson's disease. Drugs Today (Barc). 2006 Jan;42(1):21-8.
Ref 5292822007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
Ref 536923Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42.

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