Drug Information

Drug General Information
Drug ID
D00ACX
Former ID
DNC003265
Drug Name
2-chloro-5-nitro-N-phenylbenzamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551374]
Structure
Download
2D MOL

3D MOL
Formula
C13H9ClN2O3
Canonical SMILES
C1=CC=C(C=C1)NC(=O)C2=C(C=CC(=C2)[N+](=O)[O-])Cl
InChI
1S/C13H9ClN2O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,(H,15,17)
InChIKey
DNTSIBUQMRRYIU-UHFFFAOYSA-N
PubChem Compound ID
644213
PubChem Substance ID
841875, 877487, 6873016, 8707317, 11111477, 11114114, 11121686, 11122166, 11362775, 11365337, 11367899, 11370801, 11370802, 11373500, 11376061, 14824325, 17396617, 17405359, 22395870, 24278560, 24883187, 26732595, 26752209, 26752210, 26752211, 26758841, 43765920, 47719268, 47793670, 47942452, 47942453, 48392499, 50104878, 50104879, 50104880, 53777904, 53790960, 53800743, 56355093, 57408227, 77530674, 85202868, 85231138, 85787762, 88369062, 90341221, 92304217, 92310037, 99300949, 99302469
Target and Pathway
Target(s) Retinoic acid receptor RXR-alpha Target Info Inhibitor [551374]
Peroxisome proliferator activated receptor gamma Target Info Inhibitor [551374]
KEGG Pathway PPAR signaling pathway
PI3K-Akt signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Bile secretion
Hepatitis C
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancer
Small cell lung cancer
Non-small cell lung cancerhsa03320:PPAR signaling pathway
AMPK signaling pathway
Osteoclast differentiation
Huntington's disease
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway Vitamin D metabolism and pathwayP06959:CCKR signaling map ST
Pathway Interaction Database Regulation of Androgen receptor activity
RXR and RAR heterodimerization with other nuclear receptor
Retinoic acid receptors-mediated signaling
a6b1 and a6b4 Integrin signalingwnt_noncanonical_pathway:Noncanonical Wnt signaling pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by HDAC Class I
Regulation of retinoblastoma protein
Reactome RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Recycling of bile acids and salts
PPARA activates gene expression
Import of palmitoyl-CoA into the mitochondrial matrix
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Regulation of pyruvate dehydrogenase (PDH) complex
Endogenous sterols
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian ClockR-HSA-1989781:PPARA activates gene expression
WikiPathways Vitamin A and Carotenoid Metabolism
NRF2 pathway
Nuclear Receptors Meta-Pathway
Farnesoid X Receptor Pathway
PPAR Alpha Pathway
Vitamin D Receptor Pathway
Pregnane X Receptor pathway
Constitutive Androstane Receptor Pathway
Liver X Receptor Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Activation of Gene Expression by SREBP (SREBF)
Integrated Pancreatic Cancer Pathway
Adipogenesis
Circadian Clock
Nuclear Receptors
Vitamin D MetabolismWP363:Wnt Signaling Pathway Netpath
Nuclear Receptors in Lipid Metabolism and Toxicity
Differentiation of white and brown adipocyte
SREBP signalling
References
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

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