Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07PHS
|
||||
| Former ID |
DIB019670
|
||||
| Drug Name |
CXCL8
|
||||
| Synonyms |
interleukin-8
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C112H150N24O38S2
|
||||
| InChI |
InChI=1S/C112H150N24O38S2/c1-55(2)41-69(122-103(165)77(49-89(149)150)131-106(168)79(51-91(153)154)129-98(160)70(42-59-19-10-8-11-20-59)123-105(167)78(50-90(151)152)130-100(162)73(45-62-52-115-65-24-15-14-23-64(62)65)126-96(158)67(34-39-175-6)118-58(5)139)97(159)127-74(46-84(113)141)101(163)125-72(43-60-21-12-9-13-22-60)107(169)133-92(57(4)138)109(171)116-53-85(142)119-68(35-40-176-7)110(172)136-38-18-27-83(136)112(174)135-37-17-26-82(135)108(170)117-56(3)94(156)121-75(47-87(145)146)102(164)120-66(32-33-86(143)144)95(157)128-76(48-88(147)148)104(166)124-71(44-61-28-30-63(140)31-29-61)99(161)132-80(54-137)111(173)134-36-16-25-81(134)93(114)155/h8-15,19-24,28-31,52,55-57,66-83,92,115,137-138,140H,16-18,25-27,32-51,53-54H2,1-7H3,(H2,113,141)(H2,114,155)(H,116,171)(H,117,170)(H,118,139)(H,119,142)(H,120,164)(H,121,156)(H,122,165)(H,123,167)(H,124,166)(H,125,163)(H,126,158)(H,127,159)(H,128,157)(H,129,160)(H,130,162)(H,131,168)(H,132,161)(H,133,169)(H,143,144)(H,145,146)(H,147,148)(H,149,150)(H,151,152)(H,153,154)/t56-,57+,66+,67-,68-,69-,70-,71+,72-,73-,74-,75+,76+,77-,78-,79-,80+,81+,82+,83+,92-/m0/s1
|
||||
| InChIKey |
XKTZWUACRZHVAN-VADRZIEHSA-N
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | High affinity interleukin-8 receptor B | Target Info | Agonist | [2] | |
| C-X-C chemokine receptor 4 | Target Info | Agonist | [2] | ||
| KEGG Pathway | Cytokine-cytokine receptor interaction | ||||
| Chemokine signaling pathway | |||||
| Endocytosis | |||||
| Epithelial cell signaling in Helicobacter pylori infectionhsa04060:Cytokine-cytokine receptor interaction | |||||
| Axon guidance | |||||
| Leukocyte transendothelial migration | |||||
| Intestinal immune network for IgA production | |||||
| Pathways in cancer | |||||
| NetPath Pathway | TNFalpha Signaling PathwayNetPath_14:IL2 Signaling Pathway | ||||
| IL4 Signaling Pathway | |||||
| Leptin Signaling Pathway | |||||
| PANTHER Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | ||||
| Interleukin signaling pathwayP00008:Axon guidance mediated by Slit/Robo | |||||
| Pathway Interaction Database | IL8- and CXCR2-mediated signaling eventss1p_s1p3_pathway:S1P3 pathway | ||||
| CXCR4-mediated signaling events | |||||
| Syndecan-4-mediated signaling events | |||||
| HIF-1-alpha transcription factor network | |||||
| Ephrin B reverse signaling | |||||
| Reactome | Chemokine receptors bind chemokines | ||||
| G alpha (i) signalling eventsR-HSA-173107:Binding and entry of HIV virion | |||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like | |||||
| Hematopoietic Stem Cell Differentiation | |||||
| HIV Life Cycle | |||||
| Cardiac Progenitor Differentiation | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 821). | ||||
| REF 2 | Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11791-6. Epub 2004 Jul 28.Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.