Drug Information

Drug General Information
Drug ID
D0C1XS
Former ID
DNC012798
Drug Name
ZIMELIDINE
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Withdrawn from market [533389], [533528]
Structure
Download
2D MOL

3D MOL
Formula
C16H17BrN2
Canonical SMILES
CN(C)CC=C(C1=CC=C(C=C1)Br)C2=CN=CC=C2
InChI
1S/C16H17BrN2/c1-19(2)11-9-16(14-4-3-10-18-12-14)13-5-7-15(17)8-6-13/h3-10,12H,11H2,1-2H3/b16-9+
InChIKey
OYPPVKRFBIWMSX-CXUHLZMHSA-N
CAS Number
CAS 56775-88-3
PubChem Compound ID
41987
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Inhibitor [533558]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 533389The effect of zimelidine, a serotonin-reuptake blocker, on cataplexy and daytime sleepiness of narcoleptic patients. Clin Neuropharmacol. 1986;9(1):46-51.
Ref 533528Pharmacokinetic study of zimelidine using a new GLC method. Clin Pharmacokinet. 1983 Nov-Dec;8(6):530-40.
Ref 533558J Med Chem. 1984 Nov;27(11):1508-15.Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins.

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