Drug Information

Drug General Information
Drug ID
D0LC7Z
Former ID
DNC008114
Drug Name
6-(3-(pyridin-4-yl)phenyl)naphthalen-2-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529160]
Structure
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2D MOL

3D MOL
Formula
C21H15NO
Canonical SMILES
C1=CC(=CC(=C1)C2=CC=NC=C2)C3=CC4=C(C=C3)C=C(C=C4)O
InChI
1S/C21H15NO/c23-21-7-6-19-13-18(4-5-20(19)14-21)17-3-1-2-16(12-17)15-8-10-22-11-9-15/h1-14,23H
InChIKey
JKPUOZDSUARXRX-UHFFFAOYSA-N
PubChem Compound ID
24936181
Target and Pathway
Target(s) 17 alpha-hydroxylase-C17, 20-lyase Target Info Inhibitor [529160]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Glucocorticoid biosynthesis
Androgen biosynthesis
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesis
Prolactin signaling pathway
PathWhiz Pathway Androgen and Estrogen Metabolism
Steroidogenesis
Reactome Androgen biosynthesis
Glucocorticoid biosynthesis
Endogenous sterols
WikiPathways Metapathway biotransformation
Steroid Biosynthesis
Oxidation by Cytochrome P450
Metabolism of steroid hormones and vitamin D
Glucocorticoid & Mineralcorticoid Metabolism
Prostate Cancer
Phase 1 - Functionalization of compounds
References
Ref 529160Bioorg Med Chem Lett. 2008 Jan 1;18(1):267-73. Epub 2007 Oct 30.Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17.
Ref 529160Bioorg Med Chem Lett. 2008 Jan 1;18(1):267-73. Epub 2007 Oct 30.Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17.

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