Drug Information

Drug General Information
Drug ID
D0N0YX
Former ID
DNC002550
Drug Name
Beta-(2-Naphthyl)-Alanine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551374]
Structure
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2D MOL

3D MOL
Formula
C13H13NO2
Canonical SMILES
C1=CC=C2C=C(C=CC2=C1)CC(C(=O)O)N
InChI
1S/C13H13NO2/c14-12(13(15)16)8-9-5-6-10-3-1-2-4-11(10)7-9/h1-7,12H,8,14H2,(H,15,16)/t12-/m0/s1
InChIKey
JPZXHKDZASGCLU-LBPRGKRZSA-N
PubChem Compound ID
185915
PubChem Substance ID
7889282, 10260435, 10322176, 15195828, 29199655, 33507982, 46506480, 49833633, 50819238, 53796107, 57396008, 87573958, 88801743, 92709922, 113437120, 118313528, 126632387, 126650149, 126686046, 126694697, 128310932, 135164903, 135696460, 137014439, 141970871, 143438455, 143491592, 152164976, 152238801, 160800445, 160964996, 162134027, 162173186, 162764230, 163408573, 163632472, 163811307, 164798730, 170496507, 172088310, 180189897, 184562396, 196111268, 204406390, 204939106, 219400609, 223386646, 223522408, 223674925, 223959795
Target and Pathway
Target(s) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Target Info Inhibitor [551374]
Coagulation factor IIa Target Info Inhibitor [551374]
KEGG Pathway RIG-I-like receptor signaling pathwayhsa04080:Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Regulation of actin cytoskeleton
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Blood coagulation
Pathway Interaction Database p73 transcription factor network
C-MYC pathway
PDGFR-beta signaling pathway
p53 pathwaythrombin_pathway:Thrombin/protease-activated receptor (PAR) pathway
Angiopoietin receptor Tie2-mediated signaling
FOXA2 and FOXA3 transcription factor networks
PAR4-mediated thrombin signaling events
Syndecan-4-mediated signaling events
PAR1-mediated thrombin signaling events
PathWhiz Pathway Vitamin K Metabolism
Coagulation
Reactome ISG15 antiviral mechanism
Negative regulators of RIG-I/MDA5 signalingR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Cell surface interactions at the vascular wall
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
WikiPathways ISG15 antiviral mechanism
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysWP558:Complement and Coagulation Cascades
Regulation of Actin Cytoskeleton
IL1 and megakaryotyces in obesity
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Gastrin-CREB signalling pathway via PKC and MAPK
Thrombin signalling through proteinase activated receptors (PARs)
Platelet Aggregation (Plug Formation)
GPCR ligand binding
GPCR downstream signaling
Formation of Fibrin Clot (Clotting Cascade)
Cell surface interactions at the vascular wall
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

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