Drug Information

Drug General Information
Drug ID
D0I8MP
Former ID
DNC013347
Drug Name
N-(1-(3-bromobenzyl)piperidin-4-yl)-2-naphthamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528638]
Structure
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2D MOL

3D MOL
Formula
C23H23BrN2O
Canonical SMILES
C1CN(CCC1NC(=O)C2=CC3=CC=CC=C3C=C2)CC4=CC(=CC=C4)Br
InChI
1S/C23H23BrN2O/c24-21-7-3-4-17(14-21)16-26-12-10-22(11-13-26)25-23(27)20-9-8-18-5-1-2-6-19(18)15-20/h1-9,14-15,22H,10-13,16H2,(H,25,27)
InChIKey
KMQWTBGTEFASGU-UHFFFAOYSA-N
PubChem Compound ID
16725931
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [528638]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 528638Bioorg Med Chem Lett. 2007 Mar 15;17(6):1570-4. Epub 2007 Jan 8.Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the affinity for D2L, D4.2, and 5-HT2A receptors.
Ref 528638Bioorg Med Chem Lett. 2007 Mar 15;17(6):1570-4. Epub 2007 Jan 8.Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the affinity for D2L, D4.2, and 5-HT2A receptors.

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