Drug General Information
Drug ID	D08QWR
Former ID	DNC005676
Drug Name	4-benzylphthalazin-1(2H)-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529901]
Structure		Download 2D MOL 3D MOL
Formula	C15H12N2O
Canonical SMILES	C1=CC=C(C=C1)CC2=NNC(=O)C3=CC=CC=C32
InChI	1S/C15H12N2O/c18-15-13-9-5-4-8-12(13)14(16-17-15)10-11-6-2-1-3-7-11/h1-9H,10H2,(H,17,18)
InChIKey	JUCCMEHWBGPJKS-UHFFFAOYSA-N
PubChem Compound ID	616651
Target and Pathway
Target(s)	Poly [ADP-ribose] polymerase-1	Target Info	Inhibitor	[529901]
KEGG Pathway	Base excision repair
	NF-kappa B signaling pathway
PANTHER Pathway	FAS signaling pathway
Pathway Interaction Database	Integrin-linked kinase signaling
	Caspase Cascade in Apoptosis
	Notch-mediated HES/HEY network
Reactome	Dual Incision in GG-NER
WikiPathways	FAS pathway and Stress induction of HSP regulation
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Nanoparticle triggered regulated necrosis
	Corticotropin-releasing hormone
References
Ref 529901	J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.
Ref 529901	J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.

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