Drug Information

Drug General Information
Drug ID
D00GTU
Former ID
DIB020993
Drug Name
STA2
Synonyms
STA2; 11alpha-carba-9alpha,11beta-thia-Txa2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539238]
Structure
Download
2D MOL
Formula
C21H34O3S
InChI
InChI=1S/C21H34O3S/c1-2-3-6-9-17(22)13-12-16-14-18-15-20(25-18)19(16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18-,19+,20-/m0/s1
InChIKey
OVGWMUWIRHGGJP-WVDJAODQSA-N
PubChem Compound ID
5311453
PubChem Substance ID
7980665, 39341127, 57359488, 74738015, 135651090
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Agonist [534478]
Prostaglandin E2 receptor EP3 subtype Target Info Agonist [534478]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activationhsa04020:Calcium signaling pathway
cAMP signaling pathway
Regulation of lipolysis in adipocytes
Pathways in cancer
NetPath Pathway IL2 Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptorR-HSA-391908:Prostanoid ligand receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
GPCR downstream signaling
References
Ref 539238(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1939).
Ref 534478Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24.

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