Drug Information

Drug General Information
Drug ID
D0T7UG
Former ID
DNC013880
Drug Name
N-(2,3-dihydro-1H-inden-2-yl)isoquinolin-1-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530023]
Structure
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2D MOL

3D MOL
Formula
C18H16N2
Canonical SMILES
C1C(CC2=CC=CC=C21)NC3=NC=CC4=CC=CC=C43
InChI
1S/C18H16N2/c1-2-7-15-12-16(11-14(15)6-1)20-18-17-8-4-3-5-13(17)9-10-19-18/h1-10,16H,11-12H2,(H,19,20)
InChIKey
LJNDWVYBQFLXJV-UHFFFAOYSA-N
PubChem Compound ID
44591990
Target and Pathway
Target(s) Metabotropicglutamate receptor 1 Target Info Inhibitor [530023]
KEGG Pathway Calcium signaling pathway
FoxO signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 530023Bioorg Med Chem Lett. 2009 Apr 15;19(8):2190-4. Epub 2009 Mar 3.In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists.
Ref 530023Bioorg Med Chem Lett. 2009 Apr 15;19(8):2190-4. Epub 2009 Mar 3.In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists.

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