Drug Information

Drug General Information
Drug ID
D04WXI
Former ID
DIB020632
Drug Name
oxo-arpromidine
Synonyms
UR-PG136
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538710]
Structure
Download
2D MOL
Formula
C21H23FN6O
InChI
InChI=1S/C21H23FN6O/c22-16-8-6-15(7-9-16)18(19-5-1-2-10-25-19)12-20(29)28-21(23)26-11-3-4-17-13-24-14-27-17/h1-2,5-10,13-14,18H,3-4,11-12H2,(H,24,27)(H3,23,26,28,29)
InChIKey
UTJRWVBWVPCMQL-UHFFFAOYSA-N
PubChem Compound ID
25149244
PubChem Substance ID
103649355, 135651299, 163362195
Target and Pathway
Target(s) Histamine H1 receptor Target Info Agonist [527955]
Histamine H2 receptor Target Info Agonist [527955]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Gastric acid secretion
PANTHER Pathway Histamine H1 receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (q) signalling eventsR-HSA-390650:Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Secretion of Hydrochloric Acid in Parietal Cells
GPCR downstream signaling
References
Ref 538710(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1199).
Ref 527955Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines. J Pharmacol Exp Ther. 2006 Apr;317(1):139-46. Epub 2006 Jan 4.

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