Drug Information

Drug General Information
Drug ID
D08EJQ
Former ID
DNC013590
Drug Name
1-hydroxy-3-(4-(trifluoromethyl)phenyl)urea
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529488]
Structure
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2D MOL

3D MOL
Formula
C8H7F3N2O2
Canonical SMILES
C1=CC(=CC=C1C(F)(F)F)NC(=O)NO
InChI
1S/C8H7F3N2O2/c9-8(10,11)5-1-3-6(4-2-5)12-7(14)13-15/h1-4,15H,(H2,12,13,14)
InChIKey
DRFSQRMYIQLAMQ-UHFFFAOYSA-N
PubChem Compound ID
11651456
Target and Pathway
Target(s) Tyrosine oxidase Target Info Inhibitor [529488]
BioCyc Pathway (S)-reticuline biosynthesis
Eumelanin biosynthesis
L-dopachrome biosynthesis
KEGG Pathway Tyrosine metabolism
Riboflavin metabolism
Metabolic pathways
Melanogenesis
PathWhiz Pathway Riboflavin Metabolism
Tyrosine Metabolism
WikiPathways Dopamine metabolism
References
Ref 529488Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10. Epub 2008 May 4.Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation.
Ref 529488Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10. Epub 2008 May 4.Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation.

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