Drug General Information
Drug ID
D0A4IJ
Former ID
DAP000704
Drug Name
Abacavir
Synonyms
Trizivir; Ziagen; Abacavir [INN]; Abacavir (INN); Ziagen (TN); Ziagen (TM)(*Succinate salt*); [(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol; {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol; (+/-)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (+/-)-Abacavir; (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; ABC
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Approved [550653]
Therapeutic Class
Anti-HIV Agents
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL

Formula
C14H18N6O
Canonical SMILES
C1CC1NC2=NC(=NC3=C2N=CN3C4CC(C=C4)CO)N
InChI
1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1
InChIKey
MCGSCOLBFJQGHM-SCZZXKLOSA-N
CAS Number
CAS 136470-78-5
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:2360
SuperDrug ATC ID
J05AF06
SuperDrug CAS ID
cas=136470785
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Inhibitor [537321]
References
Ref 550653Abacavir (marketed as Ziagen) and Abacavir-containing Medications. FDA. 2008.
Ref 537321Quadruple nucleos(t)ide reverse transcriptase inhibitors-only regimen of tenofovir plus zidovudine/lamivudine/abacavir in heavily pre-treated HIV-1 infected patients: salvage therapy or backbone only? Curr HIV Res. 2009 May;7(3):320-6.

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