Drug General Information
Drug ID	D08XYR
Former ID	DNC013658
Drug Name	DOM
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539013]
Structure		Download 2D MOL 3D MOL
Formula	C12H19NO2
InChI	InChI=1S/C12H19NO2/c1-8-5-12(15-4)10(6-9(2)13)7-11(8)14-3/h5,7,9H,6,13H2,1-4H3
InChIKey	NTJQREUGJKIARY-UHFFFAOYSA-N
PubChem Compound ID	85875
PubChem Substance ID	7978580, 10221560, 10509196, 10516046, 15414462, 44417299, 46504804, 50004289, 57334104, 78158477, 85209384, 103111247, 103166957, 103918774, 104389663, 117533951, 124954066, 125705031, 128751983, 134350863, 134993569, 135650205, 137005387, 141288061, 160964775, 162821618, 179293624, 216396421, 226726881, 249527451, 249912022
Target and Pathway
Target(s)	5-hydroxytryptamine 2A receptor	Target Info	Inhibitor	[529336]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 539013	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 164).
Ref 529336	Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. Epub 2008 Feb 14.The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.

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