Drug Information

Drug General Information
Drug ID
D07KVP
Former ID
DIB018239
Drug Name
[3H]ancriviroc
Synonyms
[3H]SCH 351125; [3H]Sch-351125
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542927]
Structure
Download
2D MOL
Formula
C28H37BrN4O3
InChI
InChI=1S/C28H37BrN4O3/c1-5-36-30-26(22-6-8-24(29)9-7-22)23-11-15-32(16-12-23)28(4)13-18-31(19-14-28)27(34)25-20(2)10-17-33(35)21(25)3/h6-10,17,23H,5,11-16,18-19H2,1-4H3/b30-26+
InChIKey
ZGDKVKUWTCGYOA-URGPHPNLSA-N
PubChem Compound ID
9574343
PubChem Substance ID
606879, 610349, 803562, 804014, 804015, 804016, 7980801, 14763936, 23997665, 24716414, 44712403, 50067505, 57372970, 79372167, 85229935, 103280988, 104000728, 134340507, 135246542, 142056834, 179322535, 198937967, 229002252
Target and Pathway
Target(s) mRNA of CCR5 Target Info Antagonist [527892]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Toxoplasmosis
Viral carcinogenesis
NetPath Pathway TSLP Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database IL12-mediated signaling events
Reactome Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
HIV Life Cycle
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 542927(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 802).
Ref 527892Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2005 Dec;49(12):4911-9.

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