Drug General Information
Drug ID	D03ZYX
Former ID	DNC011961
Drug Name	N-hydroxyglycine derivative
Indication	Discovery agent		Investigative	[551333]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Squalene synthetase	Target Info	Inhibitor	[551333]
BioCyc Pathway	Cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
	Cholesterol biosynthesis III (via desmosterol)
	Cholesterol biosynthesis I
	Superpathway of cholesterol biosynthesis
	Epoxysqualene biosynthesis
KEGG Pathway	Steroid biosynthesis
	Metabolic pathways
	Biosynthesis of antibiotics
PANTHER Pathway	Cholesterol biosynthesis
PathWhiz Pathway	Steroid Biosynthesis
Reactome	Cholesterol biosynthesis
	PPARA activates gene expression
	Activation of gene expression by SREBF (SREBP)
WikiPathways	Statin Pathway
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Activation of Gene Expression by SREBP (SREBF)
	SREBP signalling
	Cholesterol Biosynthesis
	Cholesterol biosynthesis
References
Ref 551333	N-Hydroxyglycine derivatives as novel inhibitors of squalene synthase, Bioorg. Med. Chem. Lett. 7(23):3039-3044 (1997).
Ref 551333	N-Hydroxyglycine derivatives as novel inhibitors of squalene synthase, Bioorg. Med. Chem. Lett. 7(23):3039-3044 (1997).

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