Drug Information

Drug General Information
Drug ID
D03NCF
Former ID
DNC013043
Drug Name
Tyr-Pro-Hfe-Pro-NH2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528190]
Structure
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2D MOL

3D MOL
Formula
C29H37N5O5
Canonical SMILES
C1CC(N(C1)C(=O)C(CCC2=CC=CC=C2)NC(=O)C3CCCN3C(=O)C(CC4=<br />CC=C(C=C4)O)N)C(=O)N
InChI
1S/C29H37N5O5/c30-22(18-20-10-13-21(35)14-11-20)28(38)34-17-5-9-25(34)27(37)32-23(15-12-19-6-2-1-3-7-19)29(39)33-16-4-8-24(33)26(31)36/h1-3,6-7,10-11,13-14,22-25,35H,4-5,8-9,12,15-18,30H2,(H2,31,36)(H,32,37)/t22-,23-,24-,25-/m0/s1
InChIKey
SJJQQBJUOIMODQ-QORCZRPOSA-N
PubChem Compound ID
44413086
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Inhibitor [528190]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 528190Bioorg Med Chem Lett. 2006 Jul 15;16(14):3688-92. Epub 2006 May 8.Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics inthe position 3 or 4.
Ref 528190Bioorg Med Chem Lett. 2006 Jul 15;16(14):3688-92. Epub 2006 May 8.Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics inthe position 3 or 4.

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