Drug Information

Drug General Information
Drug ID
D00DUJ
Former ID
DNC005725
Drug Name
3-Phenanthren-9-yl-pyridine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527801]
Structure
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2D MOL

3D MOL
Formula
C19H13N
Canonical SMILES
C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)C4=CN=CC=C4
InChI
1S/C19H13N/c1-2-8-16-14(6-1)12-19(15-7-5-11-20-13-15)18-10-4-3-9-17(16)18/h1-13H
InChIKey
PNVGXPZDAYDCKZ-UHFFFAOYSA-N
PubChem Compound ID
11687499
Target and Pathway
Target(s) Cytochrome P450 11B1, mitochondrial Target Info Inhibitor [527801]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Glucocorticoid biosynthesis
Mineralocorticoid biosynthesis
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
Endogenous sterols
WikiPathways Metapathway biotransformation
Oxidation by Cytochrome P450
Metabolism of steroid hormones and vitamin D
Corticotropin-releasing hormone
References
Ref 527801J Med Chem. 2005 Oct 20;48(21):6632-42.Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis.
Ref 527801J Med Chem. 2005 Oct 20;48(21):6632-42.Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis.

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