Drug Information

Drug General Information
Drug ID
D06GJO
Former ID
DNC005640
Drug Name
(2-Methoxy-phenyl)-(5-phenyl-oxazol-2-yl)-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527458]
Structure
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2D MOL

3D MOL
Formula
C16H14N2O2
Canonical SMILES
COC1=CC=CC=C1NC2=NC=C(O2)C3=CC=CC=C3
InChI
1S/C16H14N2O2/c1-19-14-10-6-5-9-13(14)18-16-17-11-15(20-16)12-7-3-2-4-8-12/h2-11H,1H3,(H,17,18)
InChIKey
DLHCYJIQXKETIN-UHFFFAOYSA-N
PubChem Compound ID
5329844
Target and Pathway
Target(s) Vascular endothelial growth factor receptor 3 Target Info Inhibitor [527458]
mRNA of VEGFR1 Target Info Inhibitor [527458]
Vascular endothelial growth factor receptor 2 Target Info Inhibitor [527458]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Focal adhesionhsa04014:Ras signaling pathway
HIF-1 signaling pathway
Endocytosis
Focal adhesion
Transcriptional misregulation in cancer
Rheumatoid arthritishsa04014:Ras signaling pathway
VEGF signaling pathway
Proteoglycans in cancer
NetPath Pathway TNFalpha Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathway
Pathway Interaction Database VEGF and VEGFR signaling network
VEGFR3 signaling in lymphatic endotheliumglypican_1pathway:Glypican 1 network
HIF-2-alpha transcription factor network
S1P3 pathway
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2hif2pathway:HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY network
Reactome VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
WikiPathways Signaling by VEGFWP306:Focal Adhesion
Signaling by VEGF
AngiogenesisWP306:Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
Angiogenesis
References
Ref 527458J Med Chem. 2005 Mar 10;48(5):1610-9.Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.
Ref 527458J Med Chem. 2005 Mar 10;48(5):1610-9.Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.

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