TTD | Drug: D0OF1I

Drug General Information
Drug ID	D0OF1I
Former ID	DNC011646
Drug Name	8-Methoxy-2-(4-nitro-phenyl)-3H-quinazolin-4-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534774]
Structure		Download 2D MOL 3D MOL
Formula	C15H11N3O4
Canonical SMILES	COC1=CC=CC2=C1NC(=NC2=O)C3=CC=C(C=C3)[N+](=O)[O-]
InChI	1S/C15H11N3O4/c1-22-12-4-2-3-11-13(12)16-14(17-15(11)19)9-5-7-10(8-6-9)18(20)21/h2-8H,1H3,(H,16,17,19)
InChIKey	PGAMJHQYVDYIQX-UHFFFAOYSA-N
PubChem Compound ID	10851507
Target and Pathway
Target(s)	Poly [ADP-ribose] polymerase-1	Target Info	Inhibitor	[534774]
KEGG Pathway	Base excision repair
KEGG Pathway	NF-kappa B signaling pathway
PANTHER Pathway	FAS signaling pathway
Pathway Interaction Database	Integrin-linked kinase signaling
	Caspase Cascade in Apoptosis
	Notch-mediated HES/HEY network
Reactome	Dual Incision in GG-NER
WikiPathways	FAS pathway and Stress induction of HSP regulation
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Nanoparticle triggered regulated necrosis
	Corticotropin-releasing hormone
References
Ref 534774	J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).
Ref 534774	J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).

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Drug Information