Drug General Information
Drug ID	D0N7UE
Former ID	DNC003845
Drug Name	Imidazolidin-2-ylidene-quinoxalin-6-yl-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551280]
Structure		Download 2D MOL 3D MOL
Formula	C11H11N5
Canonical SMILES	C1CN=C(N1)NC2=CC3=NC=CN=C3C=C2
InChI	1S/C11H11N5/c1-2-9-10(13-4-3-12-9)7-8(1)16-11-14-5-6-15-11/h1-4,7H,5-6H2,(H2,14,15,16)
InChIKey	PVKUNRLEOHFACD-UHFFFAOYSA-N
PubChem Compound ID	10198248
Target and Pathway
Target(s)	Alpha-1B adrenergic receptor	Target Info	Inhibitor	[551280]
	Alpha-1A adrenergic receptor	Target Info	Inhibitor	[551280]
	Alpha-1D adrenergic receptor	Target Info	Inhibitor	[551280]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretionhsa04020:Calcium signaling pathway
	AMPK signaling pathway
	Salivary secretion
NetPath Pathway	IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database	LPA receptor mediated events
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
	G alpha (12/13) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Vitamin D Receptor Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	AMPK SignalingWP58:Monoamine GPCRs
	Endothelin Pathways
	GPCRs, Other
References
Ref 551280	Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995).
Ref 551280	Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995).

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