Drug Information

Drug General Information
Drug ID
D0UN9O
Former ID
DIB019969
Drug Name
GTP-14564
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526648]
Structure
Download
2D MOL
Formula
C15H10N2O
InChI
InChI=1S/C15H10N2O/c1-2-6-10(7-3-1)13-15-14(17-16-13)11-8-4-5-9-12(11)18-15/h1-9H,(H,16,17)
InChIKey
DZQLVVLATXPWBK-UHFFFAOYSA-N
PubChem Compound ID
3385203
PubChem Substance ID
4506287, 9941449, 15341863, 24844379, 26758850, 29215517, 36232097, 47424216, 57356238, 71917933, 78719544, 85787171, 89666279, 95535341, 99302685, 103567618, 112220037, 126171093, 127810021, 134964472, 135266752, 135698359, 135783795, 137394095, 140517014, 160854736, 162023265, 163687994, 166678119, 175607411, 178102605, 179236132, 228650806, 241063970, 241375771, 252156290
Target and Pathway
Target(s) Mast/stem cell growth factor receptor Target Info Inhibitor [526648]
FL cytokine receptor Target Info Inhibitor [526648]
Beta platelet-derived growth factor receptor Target Info Inhibitor [526648]
mRNA of Colony stimulating factor-1 receptor Target Info Inhibitor [526648]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Hematopoietic cell lineage
Melanogenesis
Pathways in cancer
Acute myeloid leukemia
Central carbon metabolism in cancerhsa04060:Cytokine-cytokine receptor interaction
Transcriptional misregulation in cancer
Central carbon metabolism in cancerhsa04010:MAPK signaling pathway
Calcium signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
HTLV-I infection
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Central carbon metabolism in cancer
Choline metabolism in cancer
NetPath Pathway IL3 Signaling Pathway
IL4 Signaling Pathway
KitReceptor Signaling PathwayNetPath_11:TCR Signaling Pathway
Notch Signaling Pathway
PANTHER Pathway Angiogenesis
PDGF signaling pathway
Pathway Interaction Database C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)ptp1bpathway:Signaling events mediated by PTP1B
Beta3 integrin cell surface interactions
S1P3 pathway
Nectin adhesion pathway
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PDGFR-beta signaling pathway
Validated targets of C-MYC transcriptional repression
PDGF receptor signaling networkptp1bpathway:Signaling events mediated by PTP1B
Integrins in angiogenesis
Reactome PIP3 activates AKT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascadeR-HSA-1257604:PIP3 activates AKT signaling
RAF/MAP kinase cascade
WikiPathways Kit receptor signaling pathway
Differentiation Pathway
Signaling by SCF-KIT
PIP3 activates AKT signaling
Cardiac Progenitor Differentiation
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBaseWP51:Regulation of Actin Cytoskeleton
MAPK Signaling Pathway
Osteoblast Signaling
Focal Adhesion
PDGF Pathway
Signaling Pathways in Glioblastoma
Signaling by PDGF
References
Ref 526648Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem. 2003 Aug 29;278(35):32892-8. Epub 2003 Jun 18.
Ref 526648Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem. 2003 Aug 29;278(35):32892-8. Epub 2003 Jun 18.

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