TTD | Drug: D02TKI

Drug General Information
Drug ID	D02TKI
Former ID	DNC004178
Drug Name	L-733060
Drug Type	Small molecular drug
Indication	Discovery agent		Terminated	[546077]
Structure		Download 2D MOL 3D MOL
Formula	C20H19F6NO
Canonical SMILES	C1CC(C(NC1)C2=CC=CC=C2)OCC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)<br />F
InChI	1S/C20H19F6NO/c21-19(22,23)15-9-13(10-16(11-15)20(24,25)26)12-28-17-7-4-8-27-18(17)14-5-2-1-3-6-14/h1-3,5-6,9-11,17-18,27H,4,7-8,12H2/t17-,18-/m0/s1
InChIKey	FCDRFVCGMLUYPG-ROUUACIJSA-N
PubChem Compound ID	132846
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Inhibitor	[551332]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546077	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006210)
Ref 551332	3-Benzyloxy-2-phenylpiperidine NK1 antagonists: the influence of alpha methyl substitution, Bioorg. Med. Chem. Lett. 7(23):2959-2962 (1997).

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Drug Information