Drug Information
Drug General Information | |||||
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Drug ID |
D03SGR
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Former ID |
DAP001095
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Drug Name |
Efalizumab
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Synonyms |
Raptiva; Raptiva (TN); Efalizumab (USAN/INN)
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Drug Type |
Antibody
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Therapeutic Class |
Immunomodulatory Agents
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Company |
Roche
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CAS Number |
CAS 214745-43-4
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PubChem Substance ID | |||||
SuperDrug ATC ID |
L04AA21
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Target and Pathway | |||||
Target(s) | Lymphocyte function-associated antigen 1 | Target Info | [537313] | ||
KEGG Pathway | Rap1 signaling pathway | ||||
Cell adhesion molecules (CAMs) | |||||
Natural killer cell mediated cytotoxicity | |||||
Leukocyte transendothelial migration | |||||
Regulation of actin cytoskeleton | |||||
Malaria | |||||
Staphylococcus aureus infection | |||||
HTLV-I infection | |||||
Epstein-Barr virus infection | |||||
Rheumatoid arthritis | |||||
Viral myocarditis | |||||
NetPath Pathway | TCR Signaling Pathway | ||||
RANKL Signaling Pathway | |||||
Pathway Interaction Database | Integrin family cell surface interactions | ||||
Beta2 integrin cell surface interactions | |||||
CXCR3-mediated signaling events | |||||
References | |||||
Ref 537129 | New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21. | ||||
Ref 541714 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6593). |
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