TTD | Drug: D0O7IS

Drug General Information
Drug ID	D0O7IS
Former ID	DIB018242
Drug Name	[3H]AZ11637326
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540590]
Structure		Download 2D MOL 3D MOL
Formula	C19H19FN2O
InChI	InChI=1S/C19H19FN2O/c20-17-3-1-2-13(9-17)15-8-14-10-19(23-18(14)21-11-15)12-22-6-4-16(19)5-7-22/h1-3,8-9,11,16H,4-7,10,12H2/t19-/m0/s1
InChIKey	MRVNNESNVNUKCV-IBGZPJMESA-N
PubChem Compound ID	73755064
Target and Pathway
Target(s)	Neuronal acetylcholine receptor protein, alpha-7 chain	Target Info	Agonist	[531071]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Nicotine addiction
	Chemical carcinogenesis
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
PANTHER Pathway	Nicotinic acetylcholine receptor signaling pathway
Reactome	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
WikiPathways	SIDS Susceptibility Pathways
WikiPathways	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 540590	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3971).
Ref 531071	In vitro binding characteristics of [3H]AZ11637326, a novel alpha7-selective neuronal nicotinic receptor agonist radioligand. Eur J Pharmacol. 2010 Oct 25;645(1-3):63-9.

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Drug Information