Drug Information

Drug General Information
Drug ID
D0V1UW
Former ID
DAP000774
Drug Name
Nitisinone
Synonyms
Nitisinona; Nitisinonum; Nitisone; Orfadin; Nitisinone [INN]; SC 0735; FE-0200; Nitisinone (NTBC); Nitisinone [USAN:INN]; Orfadin (TN); Nitisinone (JAN/USAN/INN); 2-(2-Nitro-4-trifluoromethylbenzoyl)cyclohexane-1,3-dione; 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione; 2-(Alpha,alpha,alpha-trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione; 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione; 2-{[2-nitro-4-(trifluoromethyl)phenyl]carbonyl}cyclohexane-1,3-dione
Drug Type
Small molecular drug
Indication Hereditary tyrosinemia type 1 [ICD9: 270.2; ICD10:E70.2] Approved [538562], [541915]
Therapeutic Class
Anticancer Agents
Structure
Download
2D MOL

3D MOL
Formula
C14H10F3NO5
InChI
InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
InChIKey
OUBCNLGXQFSTLU-UHFFFAOYSA-N
CAS Number
CAS 104206-65-7
PubChem Compound ID
115355
PubChem Substance ID
10236750, 14753104, 29296848, 46507380, 47206901, 49957875, 50139362, 56311852, 57339133, 76271421, 93167147, 102979918, 103425313, 103987675, 104398189, 123051096, 124758249, 124896666, 125432673, 126666671, 128861885, 131293388, 134223796, 134338059, 135072534, 136340345, 137003783, 140881929, 143500522, 152030782, 152134009, 152227462, 152248599, 152344367, 160821612, 160963695, 162011463, 162165008, 162203592, 163091628, 163372627, 163775323, 164045265, 164175197, 164216726, 164763350, 165702339, 174007248, 174525942, 175268251
ChEBI ID
ChEBI:50378
SuperDrug ATC ID
A16AX04
SuperDrug CAS ID
cas=104206657
Target and Pathway
Target(s) 4-hydroxyphenylpyruvate dioxygenase Target Info Inhibitor [535880], [536692]
KEGG Pathway Ubiquinone and other terpenoid-quinone biosynthesis
Tyrosine metabolism
Phenylalanine metabolism
Metabolic pathways
References
Ref 538562FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 021232.
Ref 541915(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6834).
Ref 5358804-Hydroxyphenylpyruvate dioxygenase as a drug discovery target. Drug News Perspect. 2003 Oct;16(8):493-6.
Ref 536692Experience of nitisinone for the pharmacological treatment of hereditary tyrosinaemia type 1. Expert Opin Pharmacother. 2008 May;9(7):1229-36.

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