Drug Information

Drug General Information
Drug ID
D09LPI
Former ID
DCL000129
Drug Name
BCG65-E7
Indication Anal intraepithelial neoplasia; Human papillomavirus infections [ICD9: 154, 078.1079.4; ICD10:C21, B97.7] Discontinued in Phase 3 [546672]
Company
Nventa BioPharma
Target and Pathway
Target(s) Toll-like receptor 3 Target Info Agonist [537086], [537528]
KEGG Pathway Toll-like receptor signaling pathway
Hepatitis C
Hepatitis B
Influenza A
Herpes simplex infection
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Pathway Interaction Database Endogenous TLR signaling
Reactome Ligand-dependent caspase activation
MyD88-independent TLR3/TLR4 cascade
Trafficking and processing of endosomal TLR
RIP-mediated NFkB activation via ZBP1
TRIF-mediated programmed cell death
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6 mediated induction of TAK1 complex
WikiPathways Toll-like receptor signaling pathway
Cytosolic sensors of pathogen-associated DNA
Toll-Like Receptors Cascades
MyD88-independent cascade
Trafficking and processing of endosomal TLR
Regulation of toll-like receptor signaling pathway
References
Ref 546672Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009576)
Ref 537086Medical treatment of cervical intraepithelial neoplasia II, III: an update review. Int J Clin Oncol. 2009 Feb;14(1):37-42. Epub 2009 Feb 20.
Ref 537528Serological response to an HPV16 E7 based therapeutic vaccine in women with high-grade cervical dysplasia. Gynecol Oncol. 2009 Jun 23.

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