| Drug General Information |
| Drug ID |
D03EGA
|
| Former ID |
DIB020988
|
| Drug Name |
SRT1720
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C25H23N7OS
|
| InChI |
InChI=1S/C25H23N7OS/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31/h1-8,13,15-16,26H,9-12,14H2,(H,29,33)
|
| InChIKey |
IASPBORHOMBZMY-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
48412536, 56072363, 99460882, 103563410, 104097840, 124893771, 124893772, 141483860, 152258247, 160647083, 160825152, 162158018, 162202784, 163092466, 163384436, 163840337, 165236819, 170559104, 172088859, 173019921, 186014828, 188899577, 198992051, 202562382, 204366497, 223366036, 223592782, 227223342, 244838855, 252216338, 252303031, 252451835, 252490903
|
| Target and Pathway |
| Target(s) |
NAD-dependent deacetylase sirtuin-1 |
Target Info |
Activator |
[1]
|
|---|
|
KEGG Pathway
|
FoxO signaling pathway
|
|
AMPK signaling pathway
|
|
Glucagon signaling pathway
|
|
Amphetamine addiction
|
|
MicroRNAs in cancer
|
|
PANTHER Pathway
|
p53 pathway
|
|
Pathway Interaction Database
|
p73 transcription factor network
|
|
Signaling events mediated by HDAC Class III
|
|
E2F transcription factor network
|
|
HIF-2-alpha transcription factor network
|
|
Signaling events mediated by HDAC Class I
|
|
FoxO family signaling
|
|
Regulation of Androgen receptor activity
|
|
Regulation of retinoblastoma protein
|
|
Reactome
|
RORA activates gene expression
|
|
Regulation of HSF1-mediated heat shock response
|
|
Circadian Clock
|
|
WikiPathways
|
Integrated Pancreatic Cancer Pathway
|
|
SREBF and miR33 in cholesterol and lipid homeostasis
|
|
Integrated Breast Cancer Pathway
|
|
SREBP signalling
|
|
Androgen receptor signaling pathway
|
| References |
| REF 1 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6. |
|---|
