Drug Information

Drug General Information
Drug ID
D0T3AD
Former ID
DAP000566
Drug Name
Pentostatin
Synonyms
Coforin; Covidarabine; DCF; Deoxycoformycin; Nipent; Oncopent; Vidarbine; Vira A deaminase inhibitor; CL-67310465; CO-Vidarabine; Co-V; Nipent (TN); PD-81565; PD-ADI; Pentostatin (JAN/USAN/INN); (8R)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol; (8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol; (R)-3-(2-Deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo(4,5-d)(1,3)diazepin-8-ol; 2'-DCF; 2'-Deoxycoformycin; 2'-Dexoycoformycin
Drug Type
Small molecular drug
Indication Hairy cell leukemia [ICD9: 202.4; ICD10:C91.4] Approved [468036], [536361]
Therapeutic Class
Anticancer Agents
Structure
Download
2D MOL

3D MOL
Formula
C11H16N4O4
InChI
InChI=1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1
InChIKey
FPVKHBSQESCIEP-JQCXWYLXSA-N
CAS Number
CAS 53910-25-1
PubChem Compound ID
439693
PubChem Substance ID
5328, 627752, 7847223, 7886928, 7979039, 10298426, 12013121, 14823993, 14848291, 15221795, 15221797, 36883872, 46507116, 48416395, 49846739, 56459336, 57403140, 77345581, 93166294, 103589743, 104621158, 124893764, 127882252, 135003294, 135697915, 136342513, 137240504, 140705822, 141645553, 144206967, 152258942, 160647787, 160963897, 162173052, 163913892, 170498179, 174529719, 175267509, 178101507, 179116848, 184581996, 186021002, 223398588, 223769777, 226395166, 241375751, 249701474, 251916014, 251917362, 252156268
SuperDrug ATC ID
L01XX08
SuperDrug CAS ID
cas=053910251
Target and Pathway
Target(s) Adenosine deaminase Target Info Inhibitor [535008], [538032]
BioCyc Pathway Purine nucleotides degradation
Purine deoxyribonucleosides degradation
Purine ribonucleosides degradation to ribose-1-phosphate
Adenosine nucleotides degradation
Superpathway of purine nucleotide salvage
Adenine and adenosine salvage III
KEGG Pathway Purine metabolism
Metabolic pathways
Primary immunodeficiency
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Adenine and hypoxanthine salvage pathway
Pathway Interaction Database p73 transcription factor network
C-MYB transcription factor network
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
PathWhiz Pathway Purine Metabolism
Reactome Purine salvage
WikiPathways Metabolism of nucleotides
References
Ref 468036(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4805).
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 535008Purine nucleoside analogs in indolent non-Hodgkin's lymphoma. Oncology (Williston Park). 2000 Jun;14(6 Suppl 2):13-5.
Ref 538032Acquisition of resistance to anticancer agents by overproduction of target enzymes. Nippon Rinsho. 1997 May;55(5):1030-7.

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