Drug Information

Drug General Information
Drug ID
D0GC5H
Former ID
DCL000318
Drug Name
Ramatroban
Synonyms
Baynas; Bay u 3405; Bay u 3406; Bay u-3405; Baynas (TN); Bay-u-3405; Ramatroban (JAN/INN); (+)-(3R)-3-(p-Fluorobenzenesulfonamido)-1,2,3,4-tetrahydrocarbazole-9-propionic acid; 3-(4-Fluorophenylsulfonamido)-1,2,3,4-tetrahydro-9-carbazole propanoic acid; 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid
Drug Type
Small molecular drug
Indication Perennial allergic rhinitis [ICD9: 204.0, 472.0, 477, 995.3; ICD10:C91.0, J00, J30, J31.0, T78.4] Phase 2/3 [521819], [539212]
Company
Bayer Yakuhin
Structure
Download
2D MOL

3D MOL
Formula
C21H21FN2O4S
InChI
InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1
InChIKey
LDXDSHIEDAPSSA-OAHLLOKOSA-N
CAS Number
CAS 116649-85-5
PubChem Compound ID
123879
PubChem Substance ID
7848191, 7980465, 10240891, 12014153, 14806727, 14904588, 29304055, 50064212, 50112772, 53788138, 57340633, 79986756, 92719267, 93310921, 103444835, 104048051, 104419548, 118046311, 126592924, 126628292, 126650406, 126666119, 128475209, 134338974, 135079755, 135650884, 135651196, 135698277, 136910242, 137923239, 144206069, 152106038, 152164410, 152246312, 162248522, 163305476, 163392631, 170465980, 174006902, 179149649, 186021988, 187072440, 196111770, 198937833, 204379957, 208265308, 210279843, 210282166, 223554817, 223655760
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Antagonist [536488]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 521819ClinicalTrials.gov (NCT00311051) Ramatroban/Montelukast Versus Montelukast/Placebo on the Early Allergic Reaction in Asthma Sensitive to House Dust Mite. U.S. National Institutes of Health.
Ref 539212(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1911).
Ref 536488Participation in cysteinyl leukotrienes and thromboxane A2 in nasal congestion model in Brown Norway rats. Int Immunopharmacol. 2007 Nov;7(11):1483-7. Epub 2007 Jun 26.

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