Drug Information

Drug General Information
Drug ID
D0D5LT
Former ID
DNC000679
Drug Name
GBR-12935
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467879]
Formula
C28H34N2O
InChI
InChI=1S/C28H34N2O/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27/h1-9,11-12,14-17,28H,10,13,18-24H2
InChIKey
RAQPOZGWANIDQT-UHFFFAOYSA-N
CAS Number
CAS 76778-22-8
PubChem Compound ID
3456
PubChem Substance ID
5006249, 7979374, 8152198, 11111240, 11113542, 14757892, 26751751, 29222590, 47216947, 47736666, 48035314, 49845982, 50104445, 53788636, 57321812, 75924846, 85788364, 90341152, 103095896, 103157335, 103196493, 104253497, 104303569, 117392813, 117556294, 124749810, 124880249, 124880250, 124880251, 126407603, 129101994, 135064683, 135610616, 137128375, 142054524, 162135488, 162221854, 162911735, 171578607, 174006840, 178101356, 178101357, 179235709, 186014502, 210274770, 210280403, 223582067, 227014590, 249797703, 251960719
Target and Pathway
Target(s) Type-1 angiotensin II receptor Target Info Antagonist [538041]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Renin-angiotensin system
Renin secretion
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway Angiotensin Metabolism
Muscle/Heart Contraction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Allograft Rejection
GPCR ligand binding
GPCR downstream signaling
References
Ref 467879(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4639).
Ref 538041Specific binding of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl propyl) piperazine (GBR-12935), an inhibitor of the dopamine transporter, to human CYP2D6. Biochem Pharmacol. 1997 Jun 15;53(12):1937-9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.