Drug General Information
Drug ID	D01HDD
Former ID	DNC007984
Drug Name	2-benzyl-4,5,6,7-tetrachloroisoindoline-1,3-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528834]
Structure		Download 2D MOL 3D MOL
Formula	C15H7Cl4NO2
Canonical SMILES	C1=CC=C(C=C1)CN2C(=O)C3=C(C2=O)C(=C(C(=C3Cl)Cl)Cl)Cl
InChI	1S/C15H7Cl4NO2/c16-10-8-9(11(17)13(19)12(10)18)15(22)20(14(8)21)6-7-4-2-1-3-5-7/h1-5H,6H2
InChIKey	MQFQHWBPMPPVNJ-UHFFFAOYSA-N
PubChem Compound ID	983732
Target and Pathway
Target(s)	Oxysterols receptor LXR-alpha	Target Info	Inhibitor	[528834]
	Oxysterols receptor LXR-beta	Target Info	Inhibitor	[528834]
KEGG Pathway	PPAR signaling pathway
	Non-alcoholic fatty liver disease (NAFLD)
	Hepatitis C
Pathway Interaction Database	RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome	Nuclear Receptor transcription pathway
WikiPathways	Nuclear Receptors in Lipid Metabolism and Toxicity
	Nuclear Receptors Meta-Pathway
	PPAR Alpha Pathway
	Liver X Receptor Pathway
	Adipogenesis
	SREBF and miR33 in cholesterol and lipid homeostasis
	Nuclear ReceptorsWP1982:SREBP signalling
	Nuclear Receptors
References
Ref 528834	Bioorg Med Chem Lett. 2007 Jul 15;17(14):3957-61. Epub 2007 Apr 30.Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors.
Ref 528834	Bioorg Med Chem Lett. 2007 Jul 15;17(14):3957-61. Epub 2007 Apr 30.Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors.

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