Drug Information

Drug General Information
Drug ID
D0F5VB
Former ID
DNC011962
Drug Name
PD-123319
Drug Type
Small molecular drug
Indication Discovery agent Terminated [541248], [544968]
Structure
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2D MOL

3D MOL
Formula
C31H32N4O3
InChI
InChI=1S/C31H32N4O3/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38)/t28-/m0/s1
InChIKey
YSTVFDAKLDMYCR-NDEPHWFRSA-N
PubChem Compound ID
5311345
PubChem Substance ID
7980255, 11056450, 14933623, 17396545, 39341032, 53788856, 57359443, 75807204, 93309320, 104124070, 104222555, 114155874, 129842860, 135650792, 140348197, 160671793, 164178316, 164191986, 175442823, 210274668, 210280300, 223404350, 226965476, 252472951
Target and Pathway
Target(s) Type-2 angiotensin II receptor Target Info Inhibitor [530232]
KEGG Pathway Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Renin-angiotensin system
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 541248(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 597).
Ref 544968Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001732)
Ref 530232J Med Chem. 1991 Nov;34(11):3248-60.Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.

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