Drug General Information
Drug ID	D0G3RO
Former ID	DNC008667
Drug Name	3-(4H-Imidazol-4-yl)benzenethiol
Indication	Discovery agent		Investigative	[529619]
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1=CC(=CC=C1C2=CN=CN2)S
InChI	1S/C9H8N2S/c12-8-3-1-7(2-4-8)9-5-10-6-11-9/h1-6,12H,(H,10,11)
InChIKey	PYCYXXICQDEFAY-UHFFFAOYSA-N
Target and Pathway
Target(s)	Indoleamine 2,3-dioxygenase	Target Info	Inhibitor	[529619]
BioCyc Pathway	Superpathway of tryptophan utilization
	Tryptophan degradation
	L-kynurenine degradation
	Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
	NAD de novo biosynthesis
KEGG Pathway	Tryptophan metabolism
	Metabolic pathways
	African trypanosomiasis
NetPath Pathway	TSLP Signaling Pathway
	IL5 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway	Tryptophan Metabolism
Reactome	Tryptophan catabolism
WikiPathways	Tryptophan metabolism
	Metabolism of amino acids and derivatives
References
Ref 529619	J Med Chem. 2008 Aug 28;51(16):4968-77. Epub 2008 Jul 30.Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.
Ref 529619	J Med Chem. 2008 Aug 28;51(16):4968-77. Epub 2008 Jul 30.Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.

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