TTD | Drug: D0Z5JT

Drug General Information
Drug ID	D0Z5JT
Former ID	DIB021168
Drug Name	VU0001171
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541398]
Structure		Download 2D MOL 3D MOL
Formula	C16H14N4O
InChI	InChI=1S/C16H14N4O/c1-11-16(19-15-5-3-2-4-14(15)18-11)20-17-10-12-6-8-13(21)9-7-12/h2-10,21H,1H3,(H,19,20)/b17-10+
InChIKey	WDPUHMPVZBSBGB-LICLKQGHSA-N
PubChem Compound ID	5725998
Target and Pathway
Target(s)	Metabotropic glutamate receptor 4	Target Info	Modulator (allosteric modulator)	[529883]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Glutamatergic synapse
	Taste transduction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
Reactome	G alpha (i) signalling events
Reactome	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541398	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6228).
Ref 529883	Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead. Bioorg Med Chem Lett. 2009 Feb 1;19(3):962-6.

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Drug Information