Drug Information

Drug General Information
Drug ID
D03DKZ
Former ID
DNC009704
Drug Name
VU0238429
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540227]
Structure
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2D MOL

3D MOL
Formula
C17H12F3NO4
InChI
InChI=1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3
InChIKey
CKLGZXFOLMHCMC-UHFFFAOYSA-N
PubChem Compound ID
42633508
PubChem Substance ID
81072528, 85285486, 89913510, 103614439, 104109280, 134346909, 135698908, 137148975, 162224459, 163123796, 172919853, 178100300, 204356819, 241376557, 249617934, 252157417, 252160450
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Inhibitor [530133]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 540227(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3257).
Ref 530133J Med Chem. 2009 Jun 11;52(11):3445-8.Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.

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