Drug Information

Drug General Information
Drug ID
D0WF7I
Former ID
DNC006796
Drug Name
BMS-480404
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528353]
Structure
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2D MOL

3D MOL
Formula
C22H18Cl2O5
Canonical SMILES
C1=CC=C(C(=C1)COC2=CC=CC(=C2OCC3=CC=CC=C3Cl)C(C(=O)O)O)<br />Cl
InChI
1S/C22H18Cl2O5/c23-17-9-3-1-6-14(17)12-28-19-11-5-8-16(20(25)22(26)27)21(19)29-13-15-7-2-4-10-18(15)24/h1-11,20,25H,12-13H2,(H,26,27)/t20-/m0/s1
InChIKey
NCWQPARYSYJFNI-FQEVSTJZSA-N
PubChem Compound ID
16046219
Target and Pathway
Target(s) Fatty acid-binding protein, adipocyte Target Info Inhibitor [528353]
Fatty acid-bindingprotein, epidermal Target Info Inhibitor [528353]
KEGG Pathway PPAR signaling pathwayhsa03320:PPAR signaling pathway
NetPath Pathway TCR Signaling PathwayNetPath_13:IL1 Signaling Pathway
Pathway Interaction Database AP-1 transcription factor network
Reactome Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
Transcriptional regulation of white adipocyte differentiationR-HSA-163560:Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
WikiPathways Lipid digestion, mobilization, and transport
Transcriptional Regulation of White Adipocyte Differentiation
References
Ref 528353J Med Chem. 2006 Aug 10;49(16):5013-7.NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.
Ref 528353J Med Chem. 2006 Aug 10;49(16):5013-7.NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.

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