Drug Information
Drug General Information | |||||
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Drug ID |
D0Z1HY
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Former ID |
DNC005901
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Drug Name |
4-amino-6-chlorobenzene-1,3-disulfonamide
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [529948] | ||
Structure |
Download2D MOL |
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Formula |
C6H8ClN3O4S2
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Canonical SMILES |
C1=C(C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N)N
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InChI |
1S/C6H8ClN3O4S2/c7-3-1-4(8)6(16(10,13)14)2-5(3)15(9,11)12/h1-2H,8H2,(H2,9,11,12)(H2,10,13,14)
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InChIKey |
IHJCXVZDYSXXFT-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Carbonic anhydrase | Target Info | Inhibitor | [529948] | |
Carbonic anhydrase I | Target Info | Inhibitor | [531031] | ||
Carbonic anhydrase VI | Target Info | Inhibitor | [529948] | ||
Carbonic anhydrase IX | Target Info | Inhibitor | [529948] | ||
Carbonic anhydrase II | Target Info | Inhibitor | [531031] | ||
NetPath Pathway | IL4 Signaling Pathway | ||||
EGFR1 Signaling Pathway | |||||
Pathway Interaction Database | C-MYB transcription factor networkhif1_tfpathway:HIF-1-alpha transcription factor network | ||||
PathWhiz Pathway | Gastric Acid Production | ||||
Reactome | Erythrocytes take up carbon dioxide and release oxygen | ||||
Erythrocytes take up oxygen and release carbon dioxide | |||||
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor | |||||
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | |||||
Reversible hydration of carbon dioxide | |||||
WikiPathways | Reversible Hydration of Carbon Dioxide | ||||
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway | |||||
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide | |||||
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes | |||||
References | |||||
Ref 529948 | J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. | ||||
Ref 531031 | Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. Epub 2010 Jun 22.Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. |
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