Drug Information

Drug General Information
Drug ID
D0H5VF
Former ID
DNC004228
Drug Name
RPR-113829
Drug Type
Small molecular drug
Indication Discovery agent Terminated [546523]
Structure
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2D MOL

3D MOL
Formula
C19H25N3O3S2
Canonical SMILES
CSCCC(C(=O)O)NC(=O)C1=CC=CC2=C1C=CC(=C2)NCC(CS)N
InChI
1S/C19H25N3O3S2/c1-27-8-7-17(19(24)25)22-18(23)16-4-2-3-12-9-14(5-6-15(12)16)21-10-13(20)11-26/h2-6,9,13,17,21,26H,7-8,10-11,20H2,1H3,(H,22,23)(H,24,25)/t13-,17+/m1/s1
InChIKey
YUXOGMIOPNYIQR-DYVFJYSZSA-N
PubChem Compound ID
9953221
Target and Pathway
Target(s) Protein farnesyltransferase beta subunit Target Info Inhibitor [534405]
Farnesyltransferase Target Info Inhibitor [534405]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibioticshsa00900:Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Inactivation, recovery and regulation of the phototransduction cascadeR-HSA-111465:Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransductionWP2776:Visual phototransduction
Apoptotic execution phase
References
Ref 546523Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008741)
Ref 534405J Med Chem. 1997 Jun 6;40(12):1763-7.Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase.

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