TTD | Drug: D0B3UN

Drug General Information
Drug ID	D0B3UN
Former ID	DIB020874
Drug Name	RXP470.1
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[532200]
Structure		Download 2D MOL
Formula	C35H35BrClN4O10P
InChI	InChI=1S/C35H35BrClN4O10P/c36-24-8-10-27(11-9-24)52(49,50)19-23(34(47)40-29(13-15-32(44)45)35(48)39-28(33(38)46)12-14-31(42)43)17-26-18-30(41-51-26)21-6-4-20(5-7-21)22-2-1-3-25(37)16-22/h1-11,16,18,23,28-29H,12-15,17,19H2,(H2,38,46)(H,39,48)(H,40,47)(H,42,43)(H,44,45)(H,49,50)/t23-,28+,29+/m1/s1
InChIKey	PTUCPHGSAFOJAU-MGONOCMRSA-N
PubChem Compound ID	44580458
PubChem Substance ID	103627400, 104112891, 160778786, 223366143
Target and Pathway
Target(s)	MMP-12	Target Info	Inhibitor	[532200]
NetPath Pathway	IL1 Signaling Pathway
NetPath Pathway	IL5 Signaling Pathway
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome	Collagen degradation
Reactome	Degradation of the extracellular matrix
WikiPathways	TGF beta Signaling Pathway
	Degradation of collagen
	Matrix Metalloproteinases
References
Ref 532200	Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies. J Med Chem. 2013 Feb 14;56(3):1149-59.
Ref 532200	Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies. J Med Chem. 2013 Feb 14;56(3):1149-59.

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Drug Information