Drug Information
Drug General Information | |||||
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Drug ID |
D0C2NK
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Former ID |
DIB020562
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Drug Name |
norfluoxetine
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [539317] | ||
Structure |
Download2D MOL |
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Formula |
C16H16F3NO
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InChI |
InChI=1S/C16H16F3NO/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12/h1-9,15H,10-11,20H2
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InChIKey |
WIQRCHMSJFFONW-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
515992, 841245, 3249471, 4712768, 8152798, 14849332, 29223632, 50066100, 50707944, 57322322, 85209721, 92729852, 99443277, 103131848, 103556000, 104306700, 117505046, 125607181, 125812945, 126665903, 129587205, 135062212, 135371955, 135650734, 137016413, 141566791, 152050510, 160967894, 162919696, 163640919, 179293685, 184565588, 184605154, 223682774, 223809731, 225228000, 226980400, 249897421, 252236770, 252355234
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Target and Pathway | |||||
Target(s) | 5-hydroxytryptamine 2B receptor | Target Info | Antagonist | [525929] | |
5-hydroxytryptamine 2A receptor | Target Info | Antagonist | [525929] | ||
5-hydroxytryptamine 2C receptor | Target Info | Antagonist | [525929] | ||
Kv3.1 | Target Info | Inhibitor (gating inhibitor) | [526135] | ||
WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR ligand binding | |||||
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling | |||||
SIDS Susceptibility Pathways | |||||
GPCR downstream signaling | |||||
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
References | |||||
Ref 525929 | Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 2000 Dec 5;102(23):2836-41. | ||||
Ref 526135 | Effects of norfluoxetine, the major metabolite of fluoxetine, on the cloned neuronal potassium channel Kv3.1. Neuropharmacology. 2001 Sep;41(4):443-53. |
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