Drug General Information |
Drug ID |
D0C6OD
|
Former ID |
DNC005274
|
Drug Name |
4-Chloro-N-(4-nitro-benzoyl)-benzenesulfonamide
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C13H9ClN2O5S
|
Canonical SMILES |
C1=CC(=CC=C1C(=O)NS(=O)(=O)C2=CC=C(C=C2)Cl)[N+](=O)[O-]
|
InChI |
1S/C13H9ClN2O5S/c14-10-3-7-12(8-4-10)22(20,21)15-13(17)9-1-5-11(6-2-9)16(18)19/h1-8H,(H,15,17)
|
InChIKey |
NOPPJNVGKXKZSN-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
mRNA of VEGFR1 |
Target Info |
Inhibitor |
[1]
|
Vascular endothelial growth factor receptor 2 |
Target Info |
Inhibitor |
[1]
|
Vascular endothelial growth factor receptor 3 |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Ras signaling pathway
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Rap1 signaling pathway
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Cytokine-cytokine receptor interaction
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HIF-1 signaling pathway
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Endocytosis
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PI3K-Akt signaling pathway
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Focal adhesion
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Transcriptional misregulation in cancer
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Rheumatoid arthritishsa04014:Ras signaling pathway
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VEGF signaling pathway
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Proteoglycans in cancerhsa04014:Ras signaling pathway
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NetPath Pathway
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IL2 Signaling PathwayNetPath_9:TNFalpha Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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VEGF signaling pathway
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Pathway Interaction Database
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Glypican 1 network
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HIF-2-alpha transcription factor network
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S1P3 pathway
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VEGF and VEGFR signaling network
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VEGFR1 specific signals
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Signaling events mediated by VEGFR1 and VEGFR2hif2pathway:HIF-2-alpha transcription factor network
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Beta3 integrin cell surface interactions
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Signaling events mediated by TCPTP
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SHP2 signaling
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S1P1 pathway
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Integrins in angiogenesis
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Signaling events mediated by VEGFR1 and VEGFR2
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Notch-mediated HES/HEY networkvegf_vegfr_pathway:VEGF and VEGFR signaling network
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VEGFR3 signaling in lymphatic endothelium
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Reactome
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Neurophilin interactions with VEGF and VEGFR
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VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
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VEGF binds to VEGFR leading to receptor dimerization
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Integrin cell surface interactions
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EPHA-mediated growth cone collapse
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VEGFA-VEGFR2 Pathway
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VEGFR2 mediated cell proliferationR-HSA-195399:VEGF binds to VEGFR leading to receptor dimerization
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WikiPathways
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Focal Adhesion
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Signaling by VEGF
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AngiogenesisWP306:Focal Adhesion
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Nifedipine Activity
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Cardiac Progenitor Differentiation
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AngiogenesisWP1919:Signaling by VEGF
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References |
REF 1 | J Med Chem. 2004 Oct 21;47(22):5367-80.Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. |