Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0CW4T
|
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| Former ID |
DIB020614
|
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| Drug Name |
ONO-AE-248
|
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| Synonyms |
ONO-AE-248; 11,15-O-dimethyl-PGE2
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [539231] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C22H36O5
|
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| InChI |
InChI=1S/C22H36O5/c1-4-5-8-11-17(26-2)14-15-19-18(20(23)16-21(19)27-3)12-9-6-7-10-13-22(24)25/h6,9,14-15,17-19,21H,4-5,7-8,10-13,16H2,1-3H3,(H,24,25)/b9-6-,15-14+/t17-,18+,19+,21+/m0/s1
|
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| InChIKey |
MXDQOCKVVLKVJS-QKIVIXBWSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Prostaglandin E2receptor, EP2 subtype | Target Info | Agonist | [525735] | |
| Prostaglandin E2 receptor EP3 subtype | Target Info | Agonist | [525582] | ||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| References | |||||
| Ref 525582 | Selective activation of the prostanoid EP(3) receptor reduces myocardial infarct size in rodents. Arterioscler Thromb Vasc Biol. 1999 Sep;19(9):2141-7. | ||||
| Ref 525735 | The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology. 2000 Apr;141(4):1554-9. | ||||
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