TTD | Drug: D01TRN

Drug General Information
Drug ID	D01TRN
Former ID	DIB020616
Drug Name	ONO-AE3-237
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[543186]
Structure		Download 2D MOL
Formula	C29H28N2O5
InChI	InChI=1S/C29H28N2O5/c1-18-7-12-27-26(13-18)30(3)16-23(36-27)17-35-22-10-8-20(9-11-22)29(34)31-19(2)14-24-21(15-28(32)33)5-4-6-25(24)31/h4-14,23H,15-17H2,1-3H3,(H,32,33)/t23-/m0/s1
InChIKey	PDLHJVXUGHZZQP-QHCPKHFHSA-N
PubChem Compound ID	10227892
PubChem Substance ID	15228877, 22615780, 41001322, 74687305, 137047695, 139453793, 142566947, 227246743, 246936784, 252166739
Target and Pathway
Target(s)	Prostaglandin D2 receptor	Target Info	Antagonist	[529248]
KEGG Pathway	Neuroactive ligand-receptor interaction
Pathway Interaction Database	Thromboxane A2 receptor signaling
PathWhiz Pathway	Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome	Prostanoid ligand receptors
Reactome	G alpha (s) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 543186	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8537).
Ref 529248	Prostaglandin D2 inhibits the production of IFN-gamma by invariant NK T cells: consequences in the control of B16 melanoma. J Immunol. 2008 Jan 15;180(2):783-92.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Drug Information