Drug General Information
Drug ID	D01IGU
Former ID	DIB018863
Drug Name	APA
Synonyms	1-aminooxy-3-aminopropane
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[468201]
Structure		Download 2D MOL 3D MOL
Formula	C3H10N2O
InChI	InChI=1S/C3H10N2O/c4-2-1-3-6-5/h1-5H2
InChIKey	VSZFWDPIWSPZON-UHFFFAOYSA-N
PubChem Compound ID	65020
PubChem Substance ID	8189449, 15041206, 22425646, 24902366, 24902368, 43121865, 50338680, 57315243, 57551989, 103196958, 103919167, 104332654, 125670366, 129522635, 132631105, 134350425, 135022886, 137010620, 141796018, 142919893, 162755640, 178101831, 179113908, 241169678
Target and Pathway
Target(s)	Ornithine decarboxylase	Target Info	Inhibitor	[527450]
BioCyc Pathway	Putrescine biosynthesis I
NetPath Pathway	TCR Signaling Pathway
	IL2 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Ornithine degradation
	CCKR signaling map ST
Pathway Interaction Database	Validated targets of C-MYC transcriptional activation
PathWhiz Pathway	Spermidine and Spermine Biosynthesis
References
Ref 468201	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5139).
Ref 527450	2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J Med Chem. 1992 Apr 17;35(8):1339-44.

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