Drug General Information
Drug ID
D0H4IU
Former ID
DCL000820
Drug Name
GPI-16072
Drug Type
Small molecular drug
Indication Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G64, G90.0] Phase 1 [536447]
Therapeutic Class
Analgesics
Company
MGI Pharma
Structure
Download
2D MOL

3D MOL

Formula
C6H11O7P
Canonical SMILES
C(CC(=O)O)C(CP(O)OO)C(=O)O
InChI
1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(12)13-11/h4,11-12H,1-3H2,(H,7,8)(H,9,10)
InChIKey
HKANXFJUBKMWSW-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Glutamate carboxypeptidase II Target Info Inhibitor [536374]
KEGG Pathway Alanine, aspartate and glutamate metabolism
Metabolic pathways
Vitamin digestion and absorption
NetPath Pathway TCR Signaling Pathway
TNFalpha Signaling Pathway
Reactome Amino acid synthesis and interconversion (transamination)
WikiPathways One Carbon Metabolism
References
Ref 536447Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.
Ref 536374Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.

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