Drug Information

Drug General Information
Drug ID
D01VLV
Former ID
DIB018770
Drug Name
AG-11/03
Synonyms
AG-11/03 [benzimidazole derivative]; STK220090
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541151]
Structure
Download
2D MOL
Formula
C17H17N3O2S2
InChI
InChI=1S/C17H17N3O2S2/c1-22-12-5-8-14-15(9-12)20-17(19-14)24-10-16(21)18-11-3-6-13(23-2)7-4-11/h3-9H,10H2,1-2H3,(H,18,21)(H,19,20)
InChIKey
FKTAXVGJKVSANI-UHFFFAOYSA-N
PubChem Compound ID
7342912
PubChem Substance ID
12550933, 26187907, 45816377, 47893028, 50538517, 57861317, 89827243, 107817247, 115228251, 170060177, 178102457
Target and Pathway
Target(s) FMLP receptor Target Info Agonist [531720]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway Leptin Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Human Complement System
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 541151(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5832).
Ref 531720Molecular docking of 2-(benzimidazol-2-ylthio)-N-phenylacetamide-derived small-molecule agonists of human formyl peptide receptor 1. J Mol Model. 2012 Jun;18(6):2831-43.

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