Drug Information

Drug General Information
Drug ID
D0NU5Z
Former ID
DNC006230
Drug Name
1,7,8,9-tetrahydro-1,5-diaza-trindene-4,6-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527871]
Structure
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2D MOL

3D MOL
Formula
C13H10N2O2
Canonical SMILES
C1CC2=C3C(=C4C=CNC4=C2C1)C(=O)NC3=O
InChI
1S/C13H10N2O2/c16-12-9-6-2-1-3-7(6)11-8(4-5-14-11)10(9)13(17)15-12/h4-5,14H,1-3H2,(H,15,16,17)
InChIKey
NMFHMHLMLQVGMW-UHFFFAOYSA-N
PubChem Compound ID
11506860
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [527871]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 527871Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. Epub 2005 Nov 15.Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors.
Ref 527871Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. Epub 2005 Nov 15.Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors.

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