Drug General Information
Drug ID	D0V3HG
Former ID	DNC000488
Drug Name	CV-6504
Drug Type	Small molecular drug
Indication	Discovery agent		Discontinued in Phase 2	[545370]
Structure		Download 2D MOL 3D MOL
Formula	C15H15NO2
Canonical SMILES	CC1=C(C(=O)C(=C(C1=O)C)CC2=CN=CC=C2)C
InChI	1S/C15H15NO2/c1-9-10(2)15(18)13(11(3)14(9)17)7-12-5-4-6-16-8-12/h4-6,8H,7H2,1-3H3
InChIKey	IPGAFOVEIIWXFR-UHFFFAOYSA-N
CAS Number	CAS 117574-40-0
PubChem Compound ID	93543
PubChem Substance ID	10226050, 14749588, 44424262, 57335664, 77704089, 81065591, 103283006, 104410405, 125710320, 128200574, 134339900, 135050450, 137053258, 140348626, 162378108, 162778655, 228801628
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Inhibitor	[535071], [537655]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosis
NetPath Pathway	IL4 Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 545370	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003054)
Ref 535071	A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints. Ann Oncol. 2000 Sep;11(9):1165-70.
Ref 537655	Involvement of thromboxane A2, leukotrienes and free radicals in puromycin nephrosis in rats. Kidney Int. 1991 May;39(5):920-9.

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